However, get medical help right away if you notice any symptoms diclofenac a serious allergic reactionincluding: This is not a complete list of possible side effects. If you notice 75mg effects not listed pill, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical oxycodone 5mg get high about side effects.
You may report side effects to Health Canada at Precautions See also Warning section. Before taking diclofenactell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs such as ibuprofennaproxencelecoxib ; or if you have any other allergies, diclofenac pill 75mg. This product may contain inactive ingredients, which can cause allergic reactions or other problems.
Talk to your pharmacist for more details.
Before using this medicationtell your doctor or pharmacist your medical history, diclofenac pill 75mg, especially of: Problems are more likely to occur if you are dehydrated, have heart diclofenac or kidney diseaseare an older adult, diclofenac pill 75mg, or if you take certain medications see also Drug Interactions pill.
Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your 75mg right away if you have a change in the amount of urine.
Before having surgery, tell your doctor or dentist about all the products you use including prescription drugsnonprescription drugs, and herbal products. This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy. Do 75mg drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana, diclofenac pill 75mg. This pill may cause stomach bleeding.
Daily use of alcohol and tobaccodiclofenac pill 75mg, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information. This diclofenac may make you more sensitive to the sun.
Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors, diclofenac pill 75mg. Before using this medication, women of childbearing age should talk with their doctor s about the benefits and risks such as miscarriagetrouble getting pregnant. Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancythis medication should be used only when clearly needed.
This diclofenac passes into breast milk, diclofenac pill 75mg. While there have been no pills of harm to nursing infants, consult your doctor before breast -feeding.
However, patients with known CV disease or risk factors had a higher absolute incidence of excess serious 75mg thrombotic events, due to diclofenac increased baseline rate.
Some observational studies found that this increased risk of serious CV thrombotic events began as early as the pill weeks of treatment, diclofenac pill 75mg. The increase in CV thrombotic risk has been observed most consistently at higher doses.
To minimize the potential 75mg for an adverse CV event in NSAID-treated patients, use the lowest effective dose for the shortest duration possible, diclofenac pill 75mg.
Physicians and patients should remain alert for the development of such events, throughout the entire treatment course, even diclofenac the absence of previous CV symptoms. Diclofenac should be informed about the symptoms of serious CV events 75mg the steps to take if they occur.
There is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use. Although the absolute rate of death declined somewhat after the first year post-MI, the 75mg relative risk of death in NSAID users persisted over at least the next four years of follow-up.
Gastrointestinal Bleeding, Ulceration, And Perforation NSAIDs, including diclofenac, cause serious gastrointestinal GI adverse events including inflammation, diclofenac pill 75mg, bleeding, ulcerationdiclofenac pill 75mg, and perforation of the pillstomach, small intestineor large intestinewhich can diclofenac fatal. These serious adverse events can occur at any time, with or without warning symptoms, in patients treated with NSAIDs.
However, even short-term pill is not without risk. Other factors that increase the risk of GI bleeding in pills treated 75mg NSAIDs include longer duration of NSAID therapy, concomitant use of oral corticosteroids, aspirin, anticoagulants, or selective serotonin reuptake inhibitors SSRIs ;, smoking, use of alcohol, older age, and poor general health status.
Most postmarketing reports of fatal GI events occurred in elderly or debilitated patients. Use the lowest effective dosage for the 75mg pill duration, diclofenac pill 75mg.
Avoid administration of more than one NSAID at a time Avoid use in patients diclofenac higher risk unless benefits are expected to outweigh the increased risk of bleeding.
Hepatotoxicity In clinical trials of diclofenac- containing products, diclofenac pill 75mg, meaningful elevations i. In a large, open-label, controlled trial of 3, patients treated with oral diclofenac sodium for months, patients were monitored first at 8 weeks and 1, patients were monitored again at 24 weeks. Elevations in transaminases were seen more frequently in patients with osteoarthritis than in those with rheumatoid arthritis.
75mg all meaningful elevations in transaminases were detected before pills became symptomatic, diclofenac pill 75mg. Abnormal tests occurred during the first 2 months of therapy with diclofenac in 42 of the 51 patients in all trials who developed marked transaminase elevations. In postmarketing reports, cases of drug-induced hepatotoxicity have been reported in the first month, and in some cases, 75mg first 2 months of therapy, but diclofenac occur at any time during treatment with diclofenac.
Postmarketing surveillance has reported cases of severe hepatic reactions, including diclofenac necrosisdiclofenac pill 75mg, jaundicefulminant hepatitis with and without jaundice, diclofenac pill 75mg, and pill failure.
Use of Diclofenac Potassium tablets in diclofenac with hepatic porphyria may trigger an attack. Haematological Diclofenac Potassium tablets may reversibly inhibit platelet aggregation see section 4. Patients with defects of haemostasis, bleeding diathesis or haematological abnormalities should be carefully monitored. Long term treatment All patients who are receiving long term treatment with non-steroidal, anti-inflammatory agents should be monitored as a precautionary pill eg renal function, hepatic function 75mg of liver enzymes may occur and blood counts, diclofenac pill 75mg.
This is particularly important in the elderly. Respiratory disorders In patients with asthma, diclofenac pill 75mg, seasonal allergic rhinitis, swelling of the nasal mucosa i. Therefore, special precaution is recommended in such patients readiness for emergency.
This is applicable as well for patients who are allergic to other substances, e. Like other drugs that inhibit prostaglandin synthetase activity, diclofenac pill 75mg, diclofenac sodium and other NSAIDs can precipitate bronchospasm if administered to patients 75mg from, or with a previous history of bronchial asthma. Clinical trial and epidemiological diclofenac suggest that use of diclofenac, diclofenac pill 75mg, particularly at pill dose mg daily and in long term treatment may be associated with a small increased risk 75mg arterial thrombotic events for example myocardial infarction or stroke.
As the cardiovascular risks of diclofenac may increase with dose and duration of exposure, the diclofenac duration possible and the lowest effective daily dose should be used. The patient's need for symptomatic pill diclofenac pill to therapy should be re-evaluated periodically.
Dermatological Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens- Johnson syndrome, and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs see section 4. Patients appear to be at highest risk for these reactions early in the course of therapy: Diclofenac potassium should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity.
Impaired female fertility The use of Diclofenac Potassium tablets may impair pill fertility and is not recommended in women attempting to conceive. In 75mg who may have difficulties conceiving or who are undergoing investigation of infertility, diclofenac of Diclofenac Potassium 75mg should be considered see section 4, diclofenac pill 75mg.
Co-administration of diclofenac with other systemic NSAIDs or pills may increase the risk of gastrointestinal bleeding or ulceration. Diuretics and antihypertensive agents: Therefore, the combination should be administered with caution and patients, especially the elderly, should 75mg their diclofenac pressure periodically monitored.
Patients should be adequately hydrated and pill should be given diclofenac monitoring of renal function after initiation of concomitant therapy periodically thereafter, particularly for diuretics and ACE inhibitors due to the increased risk of nephrotoxicity.
If used concomitantly, diclofenac may increase plasma concentrations of lithium Monitoring of the serum lithium level is recommended. Diclofenac can inhibit 75mg tubular renal clearance of methotrexate hereby increasing methotrexate levels, diclofenac pill 75mg.
Caution is recommended when NSAIDs, including diclofenac, diclofenac pill 75mg, are administered less than diclofenac hours before treatment with methotrexate, since blood concentrations of methotrexate may rise and the toxicity of this substance be increase. Cases 75mg serious toxicity have been reported when methotrexate and NSAIDs including diclofenac are given within 24 hours of each other.
This interaction is mediated through accumulation of methotrexate resulting from pill of renal excretion in the presence of the NSAID, diclofenac pill 75mg.
Diclofenac, like other NSAIDs, may increase the nephrotoxicity of ciclosporin due to the effect on renal prostaglandins. Therefore, 75mg should be given at diclofenac lower than those that would be used in patients not receiving ciclosporin. Anti-coagulants and anti-platelet agents: Caution is recommended since concomitant administration could increase the risk of bleeding see section 4, diclofenac pill 75mg.
Although clinical investigations do not appear to indicate 75mg diclofenac has an influence on the effect of anticoagulants, diclofenac pill 75mg, there are pills of an increased risk of haemorrhage in patients receiving diclofenac and anticoagulant concomitantly see section diclofenac.
Therefore, to be certain that no change in anticoagulant dosage is required, close monitoring of such pills is required. 75mg with other nonsteroidal anti-inflammatory agents, diclofenac in a high dose can reversibly inhibit platelet aggregation.
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